Days 1- 2
Phone in with period date or day 1 or 2 of cycle.
If the period starts at the weekend, leave a message on the answerphone together with a day
time telephone number.
Days 1 - 7
A nurse will call you back to discuss the treatment cycle - usually within 2-3 days.
A drug prescription and schedule for the treatment cycle is posted out. Advice about
obtaining the drugs will be included. The prescription is valid for 28 days The schedule
clearly states the starting date for the drug which will induce down regulation: (nasal spray
or subcutaneous injections). The date for the down regulation blood test is clearly indicated
on the schedule.
Start sniffing the nasal spray (Nafarelin or Buserelin) or injecting ( Buserelin)
These drugs block the link between the pituitary gland in the brain and the ovaries,
preventing premature ovulation and allowing accurate control of the treatment cycle. This
is the period of “down-regulation”. As the woman reaches down regulation, she should
experience a withdrawal bleed and may experience some of the side effects of the
menopause such as headaches, hot flushes and not feeling as cheerful as usual.
2 – 3
N.B. Payment will be required where appropriate before the Down Regulation blood test
Blood test at the Unit to check down-regulation has been achieved and the circulating
oestrogen level is at baseline. Once this has been achieved, then the ovarian stimulating
hormone injections can start. The injection technique is taught at this appointment
Next 8 days
Daily hormone injections of gonadotrophins (Gonal F or Puregon or Menopur) usually
given in the evening. The Nasal spray or s/c injections of Buserelin continue.
Ultrasound scans and blood tests usually every 2-3 days from this day until the follicles
have reached the correct size. Advice is then given about the late night injection of hCG.
This hormone is important as it helps mature the eggs. We will advise you of the exact day
and time to give it. This is usually between day 10 and 14 of stimulation but it can
sometimes be later than this. After you have had your hCG injection you do not take any
more of the nasal spray or injections of Buserelin.
2 days after
Oocyte retrieval is performed at the Unit and the eggs and sperm are looked after in the
laboratory. Both partners need to attend!
The day after
Patients are telephoned with the news of how many of their eggs have fertilized and given
a time to come in for embryo transfer - This will be either two, three or five days later.
2, 3 or 5 days
Unit staff perform the embryo transfer.
Pregnancy testing should be done no earlier than 16 days after egg collection
Most couples prefer to do this test at home and then ring in with the result.
The result of this pregnancy test MUST be communicated to the unit.
Administration staff will speak with you to learn of the result and one of the nurses will
contact you to discuss the result – usually the same day.